Endocrine Abstracts

Osteoporosis is a progressive disease characterized by excessive bone loss which is often accompanied by augments in marrow adiposity as a result of estrogen deficiency, metabolic abnormalities or medications. Nuclear receptor estrogen-related receptor alpha (ESRRA) has a demonstrated role in energy homeostasis and fat metabolism. To determine if ESRRA is a potential therapeutic target for regulating fat-bone balance, we generated an adipocyte-specific ESRRA knockout mice (ESR...